Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue
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منابع مشابه
Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue.
What is the organization of cerebral microvascular oxygenation and morphology that allows adequate tissue oxygenation at different activity levels? We address this question in the mouse cerebral cortex using microscopic imaging of intravascular O2 partial pressure and blood flow combined with numerical modelling. Here we show that parenchymal arterioles are responsible for 50% of the extracted ...
متن کاملLarge arteriolar component of oxygen delivery implies safe margin of oxygen supply to cerebral tissue
(a) Maximum intensity projection (MIP) of the 200-µm-thick cortical microvascular stack obtained by TPM. Blood plasma was labeled by FITC. (b) Top-view projection of the segmented microvasculature with the intravascular PO 2 measurements obtained by TPM. Mean vascular segment PO 2 measurements were color-coded and overlaid on the segmented microvascular structure. (c) MIP of the OCT image of th...
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The purpose of this study was to determine if chronic exposure to low levels of carbon monoxide (CO) in man results In tissue hypoxia. For this reason, nine smokers (more than one pack of cigarettes per day) were studied. The presence of hypoxia was assessed by measurement of red cell mass (ACM). The effect of CO on lntraerythrocytic factors involved with oxygen delivery was determined by measu...
متن کاملA model for the regulation of cerebral oxygen delivery.
On the basis of the assumption that oxygen delivery across the endothelium is proportional to capillary plasma PO2, a model is presented that links cerebral metabolic rate of oxygen utilization (CMRO2) to cerebral blood flow (CBF) through an effective diffusivity for oxygen (D) of the capillary bed. On the basis of in vivo evidence that the oxygen diffusivity properties of the capillary bed may...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms6734